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Registros recuperados: 25
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Circulating levels of inflammation-associated miR-155 and endothelial-enriched miR-126 in patients with end-stage renal disease BJMBR
Wang,Honglei; Peng,Wujian; Shen,Xuemei; Huang,Yunhui; Ouyang,Xin; Dai,Yong.
Circulating microRNAs (miRNAs) may represent a potential noninvasive molecular biomarker for various pathological conditions. Moreover, the detection of circulating miRNAs can provide important novel disease-related information. In particular, inflammation-associated miR-155 and endothelial-enriched miR-126 are reported to be associated with vascular homeostasis. Vascular damage is a common event described in end-stage renal disease (ESRD). We hypothesized that miR-155 and miR-126 may be detectable in the circulation and serve as potential biomarkers for risk stratification. In this study, we assessed miR-155 and miR-126 in the plasma of 30 ESRD patients and 20 healthy controls using real-time quantification RT-PCR. The circulating levels of miR-155 and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; End-stage renal disease; Hemodialysis; MiR-126; MiR-155.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200029
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Determination of serum aluminum, platelet aggregation and lipid peroxidation in hemodialyzed patients BJMBR
Neiva,T.J.C.; Benedetti,A.L.; Tanaka,S.M.C.N.; Santos,J.I.; D'Amico,E.A..
Aluminum (Al3+) overload is frequently associated with lipid peroxidation and neurological disorders. Aluminum accumulation is also reported to be related to renal impairment, anemia and other clinical complications in hemodialysis patients. The aim of the present study was to determine the degree of lipid peroxidation, platelet aggregation and serum aluminum in patients receiving regular hemodialytic treatment. The level of plasma lipid peroxidation was evaluated on the basis of thiobarbituric acid reactive substances (TBARS). Mean platelet peroxidation in patients undergoing hemodialysis was significantly higher than in normal controls (2.7 ± 0.03 vs 1.8 ± 0.06 nmol/l, P<0.05). Platelet aggregation and serum aluminum levels were determined by a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aluminum; Peroxidation; Hemodialysis; Platelets.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300009
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Dialysis, time and death: comparisons of two consecutive decades among patients treated at the same Brazilian dialysis center BJMBR
De-Lima,J.J.G.; da-Fonseca,J.A.; Godoy,A.D..
The survival of hemodialysis patients is likely to be influenced not only by well-known risk factors like age and comorbidity, but also by changes in dialysis technology and practices accumulated along time. We compared the survival curves, dialysis routines and some risk factors of two groups of patients admitted to a Brazilian maintenance hemodialysis program during two consecutive decades: March 1977 to December 1986 (group 1, N = 162) and January 1987 to June 1997 (group 2, N = 237). The median treatment time was 22 months (range 1-198). Survival curves were constructed using the Kaplan-Meier method and compared using the log-rank method. The Cox proportional hazard regression model was used to investigate the more important variables associated with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic renal failure; Hemodialysis; Kaplan-Meier survival curves; Risk factors.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300007
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Dialysis water treated by reverse osmosis decreases the levels of C-reactive protein in uremic patients BJMBR
Thomé,F.S.; Senger,M.; Garcez,C.; Garcez,J.; Chemello,C.; Manfro,R.C..
Atherosclerosis is a major complication of chronic renal failure. Microinflammation is involved in atherogenesis and is associated with uremia and dialysis. The role of dialysate water contamination in inducing inflammation has been debated. Our aim was to study inflammatory markers in patients on chronic dialysis, before and 3 to 6 months after switching the water purification system from deionization to reverse osmosis. Patients had demographic, clinical and nutritional information collected and blood drawn for determination of albumin, ferritin, C-reactive protein (CRP), interleukin-6, and tumor necrosis factor-alpha in both situations. Acceptable levels of water purity were less than 200 colony-forming units of bacteria and less than 1 ng/ml of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemodialysis; C-reactive protein; Dialysate water; Reverse osmosi; Inflammation; Uremia.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500018
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Effect of chloride dialysate concentration on metabolic acidosis in aintenance hemodialysis patients BJMBR
Marques,F.O.; Libório,A.B.; Daher,E.F..
Hyperchloremia is one of the multiple etiologies of metabolic acidosis in hemodialysis (HD) patients. The aim of the present study was to determine the influence of chloride dialysate on metabolic acidosis control in this population. We enrolled 30 patients in maintenance HD program with a standard base excess (SBE) ≤2 mEq/L and urine output of less than 100 mL/24 h. The patients underwent dialysis three times per week with a chloride dialysate concentration of 111 mEq/L for 4 weeks, and thereafter with a chloride dialysate concentration of 107 mEq/L for the next 4 weeks. Arterial blood was drawn immediately before the second dialysis session of the week at the end of each phase, and the Stewart physicochemical approach was applied. The strong ion gap...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chloride dialysate; Hemodialysis; Metabolic acidosis; Stewart model.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000012
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Effect of hepatitis C serology on C-reactive protein in a cohort of Brazilian hemodialysis patients BJMBR
Nascimento,M.M.; Bruchfeld,A.; Suliman,M.E.; Hayashi,S.Y.; Pecoits-Filho,R.; Manfro,R.C.; Pachaly,M.A.; Renner,L.; Stenvinkel,P.; Riella,M.C.; Lindholm,B..
Hepatitis C (HCV) is not an uncommon feature in hemodialysis (HD) patients and may be a cause of systemic inflammation. Plasma cytokine interleukin-6 (IL-6) is mainly produced by circulating and peripheral cells and induces the hepatic synthesis of C-reactive protein (CRP), which is the main acute phase reactant. The aim of this study was to investigate the influence of HCV on two markers of systemic inflammation, serum CRP and IL-6, in HD patients. The study included 118 HD patients (47% males, age 47 ± 13 years, 9% diabetics) who had been treated by standard HD for at least 6 months. The patients were divided into two groups depending on the presence (HCV+) or absence (HCV-) of serum antibodies against HCV. Serum albumin (S-Alb), plasma high sensitivity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; C-reactive protein; Interleukin-6; Hemodialysis.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500017
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Epidemiology of healthcare-associated infections among patients from a hemodialysis unit in southeastern Brazil BJID
Albuquerque,Silvia Eduara Kennerly de; Cavalcante,Ricardo de Souza; Ponce,Daniela; Fortaleza,Carlos Magno Castelo Branco.
Patients submitted to hemodialysis are at a high risk for healthcare-associated infections (HAI). Presently there are scarce data to allow benchmarking of HAI rates in developing countries. Also, most studies focus only on bloodstream infections (BSI) or local access infections (LAI). Our study aimed to provide a wide overview of HAI epidemiology in a hemodialysis unit in southeastern Brazil. We present data from prospective surveillance carried out from March 2010 through May 2012. Rates were compared (mid-p exact test) and temporally analyzed in Shewhart control charts for Poisson distributions. The overall incidence of BSI was 1.12 per 1000 access-days. The rate was higher for patients performing dialysis through central venous catheters (CVC), either...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Infection control; Hemodialysis; Bloodstream infections; Catheter-related infections.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300327
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Extended treatment with interferon and ribavirin in a hemodialysis patient with chronic hepatitis C BJID
Vigani,Aline Gonzalez; Pavan,Maria HP; Tozzo,Raquel; Gonçales,Eduardo SL; Lazarini,Maria SK; Oliveira,Alexandre Macedo de; Gonçales Jr,Fernando L.
Hemodialysis patient with chronic HCV infection,who was started on monotherapy with interferon.Qualitative HCV RNA remained positive at 12 weeks of treatment; ribavirin was associated. HCV RNA was negative at week 24 and treatment was extended to 72 weeks. HCV RNA negative six months after treatment.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Hepatitis C virus; Hemodialysis; Treatment; Interferon; Ribavirin.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200016
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Genotyping hepatitis C virus from hemodialysis patients in Central Brazil by line probe assay and sequence analysis BJMBR
Espírito-Santo,M.P.; Carneiro,M.A.S.; Reis,N.R.S.; Kozlowski,A.G.; Teles,S.A.; Lampe,E.; Yoshida,C.F.T.; Martins,R.M.B..
The present study examined the distribution of hepatitis C virus (HCV) genotypes and subtypes in a hemodialysis population in Goiás State, Central Brazil, and evaluated the efficiency of two genotyping methods: line probe assay (LiPA) based on the 5' noncoding region and nucleotide sequencing of the nonstructural 5B (NS5B) region of the genome. A total of 1095 sera were tested for HCV RNA by RT-nested PCR of the 5' noncoding region. The LiPA assay was able to genotype all 131 HCV RNA-positive samples. Genotypes 1 (92.4%) and 3 (7.6%) were found. Subtype 1a (65.7%) was the most prevalent, followed by subtypes 1b (26.7%) and 3a (7.6%). Direct nucleotide sequencing of 340 bp from the NS5B region was performed in 106 samples. The phylogenetic tree showed that...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Hepatitis C; Hepatitis C virus; Genotypes; Hemodialysis.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400013
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Hemodialysis improves endothelial venous function in end-stage renal disease BJMBR
Silva,A.M.V.; Signori,L.U.; Plentz,R.D.M.; Moreno Jr.,H.; Barros,E.; Belló-Klein,A.; Schaan,B.D.; Irigoyen,M.C..
The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 months, immediately before and after a hemodialysis session, and 10 healthy controls matched for age and gender. Endothelial function was assessed by the dorsal hand vein technique using graded local infusion of acetylcholine (endothelium-dependent venodilation, EDV) and sodium nitroprusside (endothelium-independent venodilation). Oxidative stress was evaluated by measuring protein oxidative damage (carbonyls) and antioxidant defense (total radical trapping...
Tipo: Info:eu-repo/semantics/article Palavras-chave: End-stage renal disease; Hemodialysis; Oxidative stress; Vascular endothelium.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600008
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Hepatitis B virus reactivation after treatment for hepatitis C in hemodialysis patients with HBV/HCV coinfection BJID
Wahle,Raul Carlos; Perez,Renata Mello; Pereira,Patrícia Fucuta; Oliveira,Elze Maria Gomes; Emori,Christini Takemi; Uehara,Silvia Naomi de Oliveira; Silva,Ivonete Sandra de Souza; Silva,Antônio Eduardo Benedito; Ferraz,Maria Lucia Gomes.
ABSTRACTIn coinfected HBV/HCV patients, HBV replication is usually suppressed by HCV over the time. No study to date has evaluated the HBV viremia in long-term follow-up after HCV treatment in hemodialysis patients with HBV/HCV coinfection. This study aimed to assess the evolution of HBV viremia after HCV treatment in this special population. Ten hemodialysis patients with HBV/HCV coinfection with dominant HCV infection (HBV lower than 2000 IU/mL) and significant fibrosis were treated with interferon-alpha 3 MU 3×/week for 12 months and could be followed for at least 36 months after HCV treatment. Six cases of HBV reactivation (60%) during follow-up were observed and 5/6 had been successfully treated for HCV. Patients with HBV reactivation received...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Coinfection HBV/HCV; Reactivation HBV; Hemodialysis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500533
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Hepatitis C and hemodialysis: a review BJID
Moreira,Regina Célia; Lemos,Marcilio Figueiredo; Longui,Carlos Alberto; Granato,Celso.
Hepatitis C is a serious public health problem throughout the world; chronic renal patients are highly exposed to this infection. This could be due to a failure to identify carriers of this disease or because of a lack of truly effective biosafety measures implemented in the dialysis units. Molecular biology techniques have allowed for the understanding of this virus in detail, including its replication mechanisms. Epidemiological studies have been made throughout the world, with the goal of determining the dissemination dynamics of this agent, in addition to examining the predominance of the different genotypes, and the possible mutants that are involved. Many questions must still be answered concerning infection by Hepatitis C virus (HCV); this is...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C (HCV); Hemodialysis.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400001
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Hepatitis C in hemodialysis: the contribution of injection drug use BJID
Galperim,Bruno; Mattos,Angelo A; Stein,Airton T; Schneider,Nuttiane C; Buriol,André; Fonseca,André; Lunge,Vagner; Ikuta,Nilo.
BACKGROUND: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD. METHODS: This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed: alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV),...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Hepatitis C virus; Hemodialysis; Injection drug use; Risk factors.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400020
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Is dialysis water a safe component for hemodialysis treatment in São Paulo State, Brazil? BJPS
Hilinski,Ellen Gameiro; Almodovar,Adriana Aparecida Buzzo; Silva,Fernando Pontes de Lima e; Pinto,Terezinha de Jesus Andreoli; Bugno,Adriana.
Failure on the water treatment poses hemodialysis patients at risk of injury and death. Identifying if the patients are exposed to water quality related microbiological risks is an important objective to reduce the mortality for chronic renal patients and is the main issue of this study. We evaluated the microbiological water quality used by 205 dialysis services in São Paulo State, Brazil between 2010 to 2016. The study included heterotrophic bacteria count, total coliforms research, and bacterial endotoxin determination in 1366 dialysis water samples. The number of unsatisfactory clinics for at least one microbiological parameter decreased 16.0% between 2010 to 2015 but increased 57.2% in 2016. In 2010, the most frequent unsatisfactory parameter was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemodialysis water; Endotoxin; Microbiological water quality; Hemodialysis.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100542
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Kinetics of acid-base parameters in conventional hemodialysis BJMBR
Lugon,J.R.; Pereira,G.R.M.; Strogoff-de-Matos,J.P.; Peixoto,A.J..
Details about the acid-base changes in hemodialysis are scarce in the literature but are potentially relevant to adequate management of patients. We addressed the acid-base kinetics during hemodialysis and throughout the interdialytic period in a cross-sectional study of adults undergoing conventional hemodialysis. Samples for blood gas analysis were obtained from the arterial limb of the arteriovenous fistula before the first session of the week (HD1), immediately at the end of HD1, and on sequential collections at 15, 30, 45, 60, and 120 min post-HD1. Additional blood samples were collected after ∼20 h following the end of the first dialysis and immediately prior to the initiation of the second dialysis of the week. Thirty adult patients were analyzed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemodialysis; Renal replacement therapy; Kinetics; Adequacy of dialysis; Acid-base.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100611
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Microbiological analyses of water from hemodialysis services in São Luís, Maranhão, Brazil BJM
Lima,José de Ribamar Oliveira; Marques,Sirley Garcia; Gonçalves,Azizedite Guedes; Salgado Filho,Natalino; Nunes,Paulo Cruz; Silva,Hernandes Sousa; Monteiro,Silvio Gomes; Costa,Jackson Mauricio Lopes.
Rigorous control of water quality in hemodialysis services is extremely important in order to guarantee a better quality of life of the patients submitted to this treatment. The lack of adequate water monitoring has caused the death of various patients in the past. The objective of the present study was to determine the physicochemical and bacteriological characteristics of water used by hemodialysis services in hospitals of the city of São Luís, Maranhão, Brazil. Bacteriological analyses included the membrane filter method for the determination of total coliform bacteria, the Cult-Dipcombi-TTC-agar method for heterotrophic bacteria and the limulus amebocyte lysate method for the determination of endotoxins. Eighteen water samples obtained from three...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Water; Microbiology; Hemodialysis; Contamination.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000200001
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Morbimortality study of infection in patients undergoing different types of dialysis in a renal replacement therapy center BJID
Curty,Natália Fabiane Ridão; Martins,Lucilene Fagundes da Silva; Ito,Carmen Antônia Sanches; Schafranski,Marcelo; Brites,Dorelayne Aparecida; Busato,César Roberto.
INTRODUCTION: Renal replacement therapy is the treatment of end-stage chronic kidney disease and can be performed through dialysis catheters, arteriovenous fistulas/grafts, and peritoneal dialysis. Patients are usually immunocompromised and exposed to invasive procedures, leading to high rates of infection and increased mortality.OBJECTIVES: To compare the prevalence of infection and related deaths, as well as the sensitivity profile of the putative bacteria in patients treated with peritoneal dialysis, arteriovenous fistula hemodialysis and catheter hemodialysis.METHODS: This is case-control study. Six hundred forty-four patients undergoing renal replacement therapy were selected. Patients were divided into three groups according to the modality of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hospital infection; Morbimortality; Renal replacement therapy center; Hemodialysis; Bacteria; Sensitivity profiles.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300281
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Occult hepatitis B virus infection in immunocompromised patients BJID
Jardim,Ruth Nogueira Cordeiro Moraes; Gonçales,Neiva Sellan Lopes; Pereira,Josiane Silveira Felix; Fais,Viviane Cristina; Gonçales Junior,Fernando Lopes.
Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Occult HBV infection; HBV-DNA; Anti-HBc alone; Hemodialysis; HIV; Immunosupressed patients.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400008
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Performance of urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and N-acetyl-β-D-glucosaminidase to predict chronic kidney disease progression and adverse outcomes BJMBR
Lobato,G.R.; Lobato,M.R.; Thomé,F.S.; Veronese,F.V..
Urinary biomarkers can predict the progression of chronic kidney disease (CKD). In this study, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl-β-D-glucosaminidase (NAG) were correlated with the stages of CKD, and the association of these biomarkers with CKD progression and adverse outcomes was determined. A total of 250 patients, including 111 on hemodialysis, were studied. Urinary KIM-1, NGAL, and NAG were measured at baseline. Patients not on dialysis at baseline who progressed to a worse CKD stage were compared with those who did not progress. The association of each biomarker and selected covariates with progression to more advanced stages of CKD, end-stage kidney disease, or death was evaluated by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic kidney disease; Hemodialysis; Biomarkers; Kidney injury molecule-1; Neutrophil gelatinase-associated lipocalin; N-acetyl-β-D-glucosaminidase.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000500702
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Prevalence of hepatitis C virus (HCV) infection and HCV genotypes of hemodialysis patients in Salvador, Northeastern Brazil BJMBR
Silva,L.K.; Silva,M.B.S.; Rodart,I.F.; Lopes,G.B.; Costa,F.Q.; Melo,M.E.; Gusmão,E.; Reis,M.G..
Hepatitis C virus (HCV) infection has been identified as the major cause of chronic liver disease among patients on chronic hemodialysis (HD), despite the important reduction in risks obtained by testing candidate blood donors for anti-HCV antibodies and the use of recombinant erythropoietin to treat anemia. A cross-sectional study was performed to estimate the prevalence of HCV infection and genotypes among HD patients in Salvador, Northeastern Brazil. Anti-HCV seroprevalence was determined by ELISA in 1243 HD patients from all ten different dialysis centers of the city. HCV infection was confirmed by RT-PCR and genotyping was performed by restriction fragment length polymorphism. Anti-HCV seroprevalence among HD patients was 10.5% (95% CI: 8.8-12.3)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; Seroprevalence; Viremia; Hemodialysis; Genotype; Brazil.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500005
Registros recuperados: 25
Primeira ... 12 ... Última
 

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